Online ahead of print. Dengue is an important human viral disease transmitted by insects. Many studies focused on the association between mosquito distribution and environmental factors, such as rainfall patterns, temperature and altitude. -, Lancet. A previous study in Colombia about the distribution of the Haemagogus mosquito in the sylvatic cycle found that the vector is abundant at altitudes below 2,000 meters above sea level [54]. 2020 Nov 6:1-12. doi: 10.1007/s40506-020-00237-2. There are many causes of a pleural effusion. Yes However, you may be able to find a clinic that still has a supply of YF-Vax. Therefore research on Zika is crucial. This book presents an update of the significant epidemiological and clinical research of Zika over the last years in many aspects and from a multinational perspective. Uganda. The odds of being a YF-positive county increases with the precipitation level, compared with drier areas. Adverse events associated with 17D-derived yellow fever vaccination--United States, 2001-2002. Yellow Fever affects not only humans, but monkeys as well. Yellow fever (YF), a viral infection that occurs in tropical sub-Saharan Africa and the rainforests of tropical South America, is acquired through the bite of an infected mosquito. Altitude generates temperature gradients that affect mosquito and virus viability, as well as the distribution of NHPs. For elderly travelers, the risk for severe illness and death due to YF infection should be balanced against the risk for systemic illness due to YF vaccine. https://doi.org/10.1371/journal.pntd.0005897.g002. This variable was constructed by combining natural land use and use-intensity from 40 categories of the Land Use Systems of the World for Latin American & the Caribbean (S1 File) [45, 46]. Yellow fever (YF) is a viral disease caused by the mosquito transmitted yellow fever virus (YFV) of the genus Flavivirus . The authors want to thank: the previous regional advisors and team members of the Viral Diseases Program who coordinated the yellow fever surveillance and technical cooperation activities as part of the Pan American Health Organization; the countries of the Region of the Americas for their constant input and collaboration, and the participants of the yellow fever working group for their contributions to the yellow fever risk mapping. Yellow fever results in death for 20% to 50% of those who develop severe disease. In the course of 2016, YF outbreaks were reported in Angola, the Democratic Republic of the Congo and other African countries, reaching approximately 1,000 confirmed and more than 3,000 suspected cases [10, 12]. This reaction, known as yellow fever vaccine-associated acute viscerotropic disease (YEL-AVD), causes a fairly severe disease closely resembling yellow fever caused by virulent strains of the virus. According to the literature, all neotropical NHP are susceptible and considered YFV reservoirs in wild regions [62]. Lindsey NP, Schroeder BA, Miller ER, Braun MM, Hinckley AF, Marano N, Slade BA, Barnett ED, Brunette GW, Horan K, Staples JE, Kozarsky PE, Hayes EB. For elderly travelers, the risk for severe illness and death due to yellow fever infection should be balanced against the risk of Certain individuals are at high risk for complications from both yellow fever and yellow fever vaccine, especially those who are Yes 8600 Rockville Pike https://doi.org/10.1371/journal.pntd.0005897, Editor: Christopher M. Barker, University of California, Davis, UNITED STATES, Received: February 21, 2017; Accepted: August 22, 2017; Published: September 8, 2017. Contact clinics in your area by searching the map below. Between 2005 and 2009, there were reported cases of YF in counties located along the Paran-Paraguay, the Uruguay and the Jacui and Cai rivers, all flowing towards the Southern Atlantic Ocean. Global mapping efforts exist to identify the boundaries of potential risk areas and vaccination recommendation zones [13, 35]. Please enable it to take advantage of the complete set of features! Nevertheless, while reviewing Table 1 of this study we can observe that the number of YF cases decreased only in 2007; since the location of where the vaccinations campaign took place was not available it was not possible to compare this information with the YF cases in the following period. The upsurge of human cases since December 2017 and the continuous non-human primate epizootics since September 2017 indicate a continued or resumed increase in yellow fever virus circulation in Brazil. One of the limitations of this study was that it was not possible to find disaggregated information about YF vaccination coverage by county (study unit of analysis) for the 13 endemic countries during this 15-year study period. An integrated approach for the surveillance, prevention and control of arboviral diseases was recommended by PAHO to the 55th Directing Council [92]. Funding: The author(s) received no specific funding for this work. No, Is the Subject Area "Vaccination and immunization" applicable to this article? Some countries in Africa require evidence of vaccination from all entering travelers and some countries may waive the requirements for travelers staying less than 2 weeks that are coming from areas where there is no current evidence of significant risk for contracting yellow fever. Compared to counties with no YF cases (median of two NHP genera), we found a significant difference between groups (Mann-Whitney U test = 59, p <0.001). Data Availability: All relevant environmental data are within the paper and its Supporting Information files. Vellozzi C, Mitchell T, Miller E, Casey CG, Eidex RB, Hayes EB. The 2016/2017 YF outbreak in Brazil is a recent example of how YF could emerge [18]. https://doi.org/10.1371/journal.pntd.0005897.g003. Modes of Transmission. Epub 2008 Sep 20. The median county rainfall in the study area was of 1,384 mm (Fig 4). The objective of this study is to identify spatial patterns and the relationship between key geographic and environmental factors with the distribution of yellow fever human cases in the Americas. Some of these factors involve latitude, altitude, orography slope and orientation, land mass size, ecosystem features as rain and temperature, fauna and flora, besides human activity [19, 20]. Validation, Bethesda, MD 20894, Help The following diseases may cause pleural effusion: Heart failure; sarcoidosis, yellow-nail syndrome, familial Mediterranean fever. Sylvatic (jungle) YF is the predominant transmission cycle in the Americas [7]. In December of 2015, the Pan American Health Organization (PAHO) published an Epidemiological Alert about the risk of YFV and the occurrence of epizootic and human cases in certain areas of the Americas [18]. No statistically significant low-high or low-low clusters were found in the whole area. Yellow Fever virus 17D Risk Group 2 Biosafety Level 2. The number of different genera of NHP hosts (Alouatta, Aotus, Callithrix, Saguinus, Ateles, Cebus, Saimiri, Lagothrix) by county were calculated based on the terrestrial mammal digital cartography and the databased provided by the International Unit for Conservation of Nature. 3 Yellow fever (YF) vaccination is generally not recommended in areas where there is low potential for YF virus exposure. So, the infection risk increases when you visit or reside in tropical South America and sub-Saharan African regions. Centers for Disease Control and Prevention (CDC). Because the cases were unusual and adverse events following YF vaccination had not been studied, we estimat If travel to high-risk areas is unavoidable during pregnancy and the risks of exposure to yellow fever virus are felt to outweigh the risks of the vaccine (e.g., travel to high-risk area unavoidable and high level of protection against mosquito exposure not feasible), ACIP, CDC, and AAP state that yellow fever vaccine can be administered. Risk factors ID'd for conversion from RIS to multiple sclerosis. As yellow fever is frequently fatal for those who have not been vaccinated, vaccination is recommended for all travellers (with few exceptions, Chapter 6) visiting areas where there is a risk of yellow fever transmission. Methodology, As a proximate extension of the Peruvian high-high cluster, Bolivia showed contiguous YF clustered areas in La Paz, Beni, Cochabamba and Santa Cruz. Investigation, All confirmed cases, first defined as probable, need to meet one of the additional criteria: detection of YFV-specific immunoglobulin M (IgM); detection of a fourfold increase in YFV antibody titers between acute and convalescent serum samples; or detection of YFV-specific neutralizing antibodies. Future studies are needed to understand the behavior and the role in the transmission of different genera of NHP hosts present in YF areas. The cycle involves the circulation of YFV between various species of non-human primates (NHP) and tree-dwelling mosquitoes from the genus Haemagogus, the main vector of jungle YF in the Americas, especially Haemagogus janthinomys and Haemagogus spegazzini, which inhabit the rainforest canopy. Geo-environmental related factors (described previously) were included in the analysis as independent variables. YF is caused by yellow fever virus (YFV), which is transmitted to humans through the bite of an infected mosquito, and YF was one of the most feared diseases in the New World before the 20th century [2]. Curr Treat Options Infect Dis. Finally, severe allergic reactions to the vaccine are possible. Yellow fever (YF) is a potentially lethal mosquito-borne viral hemorrhagic fever endemic in Africa and South America. Yellow fever is a type of disease caused by viruses and it is transmitted through a mosquito intermediaries. The disease is characterized by high fever, as well as eyes and skin that is yellow due to decreased liver function. The dependent variable was dichotomized according to the presence of YF reported during the study period: coded as 1 if the county had reported at least one case during the last 15 years or 0 if no cases were reported during this time. Ahead of that, health experts have gone out to communities to educate the public on risk factors, and prevention. For more information about PLOS Subject Areas, click Yes During this outbreak, a worker returned to China from Africa with YF [82]; however, due to low temperatures in China and the absence of urban vectors, the spread of yellow fever to Asia, a region without circulation of this virus, was contained. https://doi.org/10.1371/journal.pntd.0005897.g004. In this study, we modelled subnational variation in risk of yellow fever across all risk zones and predicted receptivity to yellow fever virus transmission outside risk areas, using a model that is based on yellow fever infection data, vaccination coverage rates, and a range of environmental and biological covariates. Mosquito bite avoidance and yellow fever vaccination is recommended for travellers visiting countries where there is a risk of YF virus transmission. Zonal statistics (min, mean, max, standard deviation, range) were calculated to measure counties lowest altitude, mean temperature and mean total annual rain. Unable to load your collection due to an error, Unable to load your delegates due to an error. For those counties located at an altitude from 318 to 784 masl, the odds was 5.33 (p = 0.01). These factors in turn are influenced by the tools with which public ic re-emergence of yellow fever epidemics as the yellow fever virus was African cities, increasing the risk of explosive urban outbreaks of Dengue [19]. Comparative study of adverse events after yellow fever vaccination between elderly and non-elderly travellers: questionnaire survey in Japan over a 1-year period. Out of the 13 endemic countries, five did not report YF human cases during the 15-year study period: French Guiana, Guyana, Panama, Suriname, and Trinidad and Tobago. Jentes E, Poumerol G, Gershman M et al. No, Is the Subject Area "Brazil" applicable to this article? The variables in this study were defined as follows: Based on PAHOs recommended case definition, a probable YF case has one of the following: presence of YFV IgM antibodies in the absence of YFV immunization, within 30 days before onset of illness; positive postmortem liver histopathology; or epidemiological link to a confirmed case or outbreak. A set of cartographic digital databases and attributes were assembled and shaped using different sources. Yellow fever is one of the few diseases for which a certificate of vaccination is required for entry into countries where there is evidence of persistent or periodic disease transmission, regulated under the International Health Regulations [34]. Whereas in Africa the majority of simian species have greater resistance to YFV infection and rarely develop the disease, due to long-term adaptation to the virus, in the Americas, neotropical species of monkeys are prone to developing fatal infections [32, 33]. Yellow fever virus (YFV) is distinct from other viral hemorrhagic fevers by the severe injury to the liver causing the It should generally not be given to people who are immunocompromised. Higher temperatures increased the odds of being a YF county. In the final model of this study, for every one additional genus of NHP host present in the area, the odds of YF occurrence doubled, suggesting that primate diversity can be associated with environmental factors that favor the presence of YF human cases. DOI: 10.4103/0972-4958.213955 Context: Yellow fever (YF) is an infection which could lead to hemorrhage, and malaria is a highly prevalent infectious disease in Africa. Writing original draft, Affiliation Bookshelf This offers innovative possibilities of linking public health data to potential sources of environmental exposure [86]. By the end of the 19th century, advances in research by Walter Reed and his team demonstrated this virus was able to spread between humans through the vector Aedes mosquitos. Perhaps there were fluctuations of temperature and rain within the tropical habitats that altered the natural cycles and created propitious circumstances for the spread of the virus, sickening NHP and humans in the area. 8. Susan Lederer provides the first full-length history of early biomedical research with human subjects. 2008 Nov 11;26(48):6077-82. doi: 10.1016/j.vaccine.2008.09.009. In 2012, a group of YF specialists met in Panama to review the disease situation in the Americas in order to improve preparedness and response in terms of epidemiological, epizootic, entomological and laboratory surveillance [14]. This is the third edition of this publication which contains the latest information on vaccines and vaccination procedures for all the vaccine preventable infectious diseases that may occur in the UK or in travellers going outside of the UK Risk of yellow fever vaccine-associated viscerotropic disease among the elderly: a systematic review. It only affects people who come in contact with mosquitoes carrying the YF virus. (HealthDay)Three factors are associated with an increased risk for onset of Epub 2008 Sep 20. It also allows the use of information from other sources/sectors and helps to gather and visualize statistics. Risk factors. The majority of recent publications about NHP and YF in South America are related to Alouatta [6365]. Understanding the complexity of ecological interactions in a geographical region is important for prediction, prevention and control measures of vector-borne diseases [37]. Preventive Medicine and Epidemiology Department, Hospital Universitari Vall dHebron, Universitat Autonoma de Barcelona, Barcelona, Spain, Roles Counties with moderate annual temperatures between 14.420.0C had an OR of 4.12 for a yellow fever positive county compared to the reference group (counties with mean annual temperature between 3.014C). In order to study the effect of human activity on the environment, we analyzed land use categorizing its use intensity as a proxy of agricultural frontier over natural areas. After the discovery of the urban transmission cycle, including the identification of vectors and hosts, and the development of the vaccine in the 1930s, the public fear and epidemiological impact were abridged [3]. 2020 Jul 29;5(3):125. doi: 10.3390/tropicalmed5030125. No census of NHP by county was found in open-access databases. CAUSES, INCIDENCE AND RISK FACTORS: Yellow fever is caused by an arbovirus, a small virus transmitted by the bite of mosquitoes. Temperature has long been known to influence the extrinsic incubation period of YFV in Ae. Writing review & editing. The main factors associated with death were changes in renal excretion and elevated serum transaminases, especially ALT. Among the YF-positive counties a spatial autocorrelation was observed exposing clustered areas with comparable number of YF cases. Yellow fever was present in 286 counties during the study period, which represent merely 3.4% out of the total 8,465 counties studied. This vaccine is used to help prevent yellow fever in adults and children who are at least 9 months old. The year 2003 presented the highest number of cases in the time period (234 cases). Safety of the yellow Fever vaccine: a retrospective study. Yellow fever (YF) is a viral disease transmitted by mosquitoes causing a spectrum of disease from mild to severe symptoms. Can Comm Dis Rep 2010;36(ACS-11):1-23. Counties without YF had a median latitude of 14.02 degrees south. occupy most of the area studied in this paper. Others, like the Aotus spp., are less exposed to biting of key vectors species due to their nighttime activity [7]. Recent studies have also confirmed the relevance of geographic factors, such as low latitudes, where infected vectors and hosts overlap with suitable conditions for amplifying the transmission [8, 10]. Epub 2013 Oct 10. Yellow fever transmission may occur at altitudes up to 2,300 meters in the Americas and possibly higher in Africa [22]. The World Health Organization considers 13 countries endemic for YFV in the Americas. Dr Lihinag Li Meng Sylvain says the Ministry of Public Health will organize an immunization campaign soon. Yellow Fever virus is transmitted to humans from infected non-human primates and other humans by the bite of Aedes in Africa and Haemagogus mosquitoes in South America. eCollection 2021. The objective of this study was to identify spatial patterns and the relationship between key geographic and environmental factors with the distribution of YF human cases in the Americas.
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