arsine gas poisoning

Arsine is a colorless, flammable, and highly toxic gas. Arsine is the gaseous and the most toxic form of the element, arsenic. First, get fresh air by leaving the area where the arsine was released. It is a colourless, non-irritant gas that smells like garlic. These are called inorganic arsenic compounds. After arsine enters the bloodstream, it damages the red blood cells and can lead to signs and symptoms of hemolytic anemia as a direct result of this damage. (However, showing these signs and symptoms does not necessarily mean that a person has been exposed to arsine): If people survive the initial exposure, long-term effects may include kidney damage; numbness and pain in the extremities; and neuropsychological symptoms such as memory loss, confusion, and irritability. 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However, exposure to high doses of arsine can be fatal immediately. Stibine is a toxic gas that has effects similar to those of arsine, but stibine is not encountered as frequently as arsine. AsH3 is also well known in forensic science because it is a chemical intermediate in the detection of arsenic poisoning. Circulatory collapse may occur and be followed by death within a few hours. Route of Exposure: Inhalation is the major route of arsine exposure. Readily absorbed via GI tract and inhalation, poorly via skin Arsine gas does not produce arsenic intoxication. At lower doses, people may not know they have been exposed to arsine, because it has no odor. Extremely toxic by inhalation; has been used as a military poison gas. It is a nonirritating gas with a mild odor (odorless at low doses) that is used in the semiconductor and metals refining industries. After inhalation of arsine gas, it causes rapid destruction of RBCs, leading to hypoxia and renal failure. Arsine is water soluble. Death is almost instantaneous. Arsine gas poisoning: the importance of exchange transfusions in severe cases. Uses of the chemical The health department or emergency personnel will arrange for further disposal. Stibine, on the other hand, has a strong odor, so people will probably be aware that they may have been exposed to something. This process is called dialysis. Note: The actual clinical manifestations of arsine exposure may be more variable than the syndrome described above. Arsine is … Arsine is similar to a gas called stibine, which is formed when the metal antimony comes in contact with an acid. The object was to obtain reliable data for the toxicity of the gas and further information regarding the mechanism bywhichit causes death. If the arsine release was indoors, get out of the building. Arsenic (As) is a nearly tasteless odorless toxic metalloid element that is found ubiquitously in the environment. ARSINE GAS Arsine gas acts as poison to haemoglobin and cause haemolysis. To receive email updates about this page, enter your email address: Centers for Disease Control and Prevention. At low levels, arsine is a potent hemolysin, causing dose-dependent intravascular hemolysis. You will be subject to the destination website's privacy policy when you follow the link. The gas destroys red blood cells, which can lead to kidney failure. For more information on evacuation during a chemical emergency, see “Facts About Evacuation” at. Arsine is the most toxic form of arsenic, doing harm when ingested in even small quantities. Patients with significant hemolysis may require folate or iron supplementation. C S Hesdorffer , F J Milne , J Terblanche , and A M Meyers Copyright and License information However, exposure to high doses of arsine can be fatal immediately. Arsine or Stibine Poisoning. To receive email updates about this page, enter your email address: Centers for Disease Control and Prevention. Avoid touching contaminated areas of the clothing. Exposure to arsine (SA) in … The classic triad of symptoms in sublethal arsine exposures includes abdominal pain, hematuria, and jaundice. Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease. Arsine Exposures and Health Risks. Introduction: Exposure to arsine gas can cause fatal hemolysis and multiorgan damage. To assist the reader, examples of exposure estimation and risk characteriza-tion are provided in CICADs, whenever possible. Exposure can cause chills, fever, dizziness, disorientation and abdominal pains. Do not handle the plastic bags yourself. When the local or state health department or emergency personnel arrive, tell them what you did with your clothes. Do not put the contacts back in your eyes (even if they are not disposable contacts). Quickly take off clothing that may have arsine on it. Anything that touches the contaminated clothing also should be placed in the bag. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. If the arsine release was outside, move away from the area where the arsine was released. Arsenic comes in four common valence states: As(o), As(III), As(V) and Arsine gas and three common forms: inorganic salt, organic salt, and gaseous form. Any clothing that has to be pulled over the head should be cut off the body instead of pulled over the head. Long-term exposure limit (8-hour TWA reference period) Short-term exposure limit (15-minute reference period) Long-term exposure limit (8-hour TWA reference period) 8-hour TWA workday and a 40-hour workweek; Common Name CAS Number Formula ppm mg.m-3 ppm mg.m-3 ppm mg.m-3 ppm; Ammonia: 7664-41-7: NH3 : 25: 18: 35: 25: 50: 35: 25: Arsine : 7784-42-1: AsH3: 0.05: 0.16: 0.05: 0.2: … However, contact with liquid arsine may result in frostbite injury. The old (but extremely sensitive) Marsh test generates AsH3 in the presence of arsenic. Depending on the intensity of exposure to arsine, symptoms are likely to occur within the first 24 hours after exposure. Arsine is the gaseous and the most toxic form of the element, arsenic. Arsine is extremely toxic and is lethal at low concentrations. Arsine is used most commonly in the semiconductor and metals refining industries. It is a nonirritating gas with a mild odor (odorless at low doses) that is used in the semiconductor and metals refining industries. It has a garlic-like or fishy odor that can be detected at concentrations of 0.5 ppm and above. Arsine gas (ASH 3) has been known for centuries to be a potent hemolytic agent but the exact mechanism of this effect is still not understood at the molecular level. After you have washed yourself, place your clothing inside a plastic bag. If you are near a release of arsine, emergency coordinators may tell you to either evacuate the area or to “shelter in place” inside a building to avoid being exposed to the chemical. For more information about cleaning your body and disposing of your clothes after a chemical release, see “Chemical Agents: Facts About Personal Cleaning and Disposal of Contaminated Clothing” at, Regional poison control center: 1-800-222-1222, Centers for Disease Control and Prevention. The extent of poisoning caused by arsine depends on how much arsine a person has been exposed to and how long the person was exposed. Despite sometimes exhibiting a garlic-like odor and being colorless and generally non-irritating, arsine is a flammable and highly toxic gas. Because arsine is nonirritating and produces no immediate symptoms, persons exposed to hazardous levels may be unaware of its presence. Washing with soap and water will help protect people from any chemicals on their bodies. Arsine causes massive hemolysis and results in anemia, jaundice, and hemoglobinuric renal failure. It is slightly soluble in water, and aqueous solutions are neutral. Inorganic arsenic is metallic or a metalloid element that forms a number of poisonous compounds. Arsenic poisoning, or arsenicosis, occurs after the ingestion or inhalation of high levels of arsenic. Some people may need to have their blood cleaned by a machine if their kidneys fail. If you wear eyeglasses, wash them with soap and water. In industry, it can be found in a gaseous form termed arsine gas that is very toxic when inhaled. Arsine gas exposure is a rare occupational event and can be completely prevented with the use of appropriate protective gear. On exposure to light, moist arsine decomposes quickly, depositing shiny black arsenic. Arsine is stored under pressure in glass lined cannisters. It is soluble in water, and slightly soluble in alcohol and alkalies. Red cell transfusion may be necessary to replace the patient’s hemolyzed red cells. 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