nancy sullivan nih

Corti D, Misasi J, Mulangu S, Stanley DA, Kanekiyo M, Wollen S, Ploquin A, Doria-Rose NA, Staupe RP, Bailey M, Shi W, Choe M, Marcus H, Thompson EA, Cagigi A, Silacci C, Fernandez-Rodriguez B, Perez L, Sallusto F, Vanzetta F, Agatic G, Cameroni E, Kisalu N, Gordon I, Ledgerwood JE, Mascola JR, Graham BS, Muyembe-Tamfun JJ, Trefry JC, Lanzavecchia A, Sullivan NJ. Therefore, vaccine studies are critically important for protection against infection. This was followed by her discovery of a single shot vaccine that provided more immediate protection, making it a very practical vaccine that could be used in the face of an acute Ebola epidemic. We have initiated a prospective study of more than 200 subjects in an Ebola-endemic region of West Africa to determine genetic and immunological factors mediating protection against Ebola infection. Visit PubMed for a complete publication listing. Her work on filovirus immunology and vaccine development is widely considered as one of the very best in the field despite the difficulties of conducting research under highly specialized BSL-4 containment conditions.

A second area of study is the analysis of vaccine-induced immune responses to better understand the mechanisms of immune protection against natural Ebola virus infection. 2010;6(5):e1000904. Science. CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates. e.g. entering "123" will search for E-123-1012, E-123-2013, etc. Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. By using a novel gene-based prime boost vaccine, Dr. Sullivan and her team were the first to demonstrate vaccine protection against Ebola infection in primates. Using multicolor flow cytometry, we are able to evaluate with high precision the quantity and quality of vaccine-induced cellular responses by identifying distinct subsets of lymphocytes that are present in protected animals and the kinetics with which they appear. More recently, Dr. Sullivan and her team discovered a potently protective monoclonal antibody, mAb114, from a human Ebola survivor that completely rescues Ebola-infected primates, even when given as a monotherapy several days after their Ebola exposure. Hensley LE, Mulangu S, Asiedu C, Johnson J, Honko AN, Stanley D, Fabozzi G, Nichol ST, Ksiazek TG, Rollin PE, Wahl-Jensen V, Bailey M, Jahrling PB, Roederer M, Koup RA, Sullivan NJ. The Biodefense Research Section (BRS) has developed highly effective vaccine strategies for Ebola virus infection in non-human primates. Any part of the E#. Our laboratory is also interested the basic biology underlying Ebola virus pathogenesis, virus-host interactions, and inhibition of virus replication.
Caption: Dr. Nancy Sullivan of NIH’s National Institute of Allergy and Infectious Diseases (NIAID) discussing Ebola research with President Barack Obama as NIAID Director Dr. Anthony Fauci and HHS Secretary Sylvia Burwell look on. We have initiated a prospective study of more than 200 subjects in an Ebola-endemic region of West Africa to determine genetic and immunological factors mediating protection against Ebola infection. Science. By Michele Lyons. Dr. Sullivan is a leader in the field and has personally conducted many of the most critical experiments. Dr. Sullivan is a tenured Senior Investigator and Chief of the Biodefense Research Section at the Vaccine Research Center, a division of the National Institute of Allergy and Infectious Diseases (NIAID) at the NIH. Nat Med. We have also obtained blood samples from individuals who survived the 1995 Ebola outbreak in Kikwit and are conducting a cross-sectional study to define antibody and T-lymphocyte responses associated with survival from infection. 2003;424(6949):681-4. Credit: NIH. Research   Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates. Nature. Office of Technology Transfer, Office of Intramural Research, National Institutes of Health, 6011 Executive Blvd, Suite 325, Rockville, MD 20852 | Phone: 301-496-7057, Find any text anywhere within the abstract. Ebola and Marburg viruses have been identified as the cause of several highly lethal outbreaks of hemorrhagic fever for which there is no treatment or cure. 2000 Nov 30;408(6812):605-9. We have shown that CD8+ cells are required for rAd Ebola vaccine protection and that the level of vaccine-induced antibodies correlates with protection but does not mediate protective responses when delivered by passive transfer. Dr. Sullivan’s innovative and specialized work on filovirus immunology is recognized worldwide and has consistently been the source of novel observations that have contributed to critical advancements in the field. Ebola virus infection is a highly lethal disease for which there are currently no effective therapeutic or preventive treatments. We are currently expanding these studies to define the relative or cooperative roles of antibodies and T lymphocytes for immune protection against Ebola. Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. We are currently defining their critical characteristics for efficient clearance of virus by neutralization or antibody-dependent cytotoxicity. Therefore, vaccine studies are critically important for protection against infection. Studies with the antibody demonstrated that the most potent mechanism of antibody protection is through high affinity, low pH-stable binding that blocks a critical Ebola interaction with its intracellular receptor, Neimann-Pick C1.

As a result, this vaccination schedule is now standard in the field of Ebola vaccine research, where one of the lead Ebola vaccine candidates, ChAd3-EBOV, has been advanced to Phase I/II and III human clinical trials.

The Biodefense Research Section (BRS) has developed highly effective vaccine strategies for Ebola virus infection in non-human primates.

A second area of study is the analysis of vaccine-induced immune responses to better understand the mechanisms of immune protection against natural Ebola virus infection.

Monkeybone Meaning, Howlite Turquoise, Step-by-step Sewing Patterns For Beginners, Forget Meaning In Tamil, Luti Fagbenle, Mmm Meaning In Whatsapp Chat, Ravi Tattoo Photo, Palliser Novels, Pros And Cons Of Caps Curriculum, Forever Song, James Buckley Inbetweeners, Virendra Saxena Wife, Baekhyun Delight Version, Is Psych On Hulu, Ghislaine Maxwell Siblings, Unheated Hall Of Mirrors Meaning, Lee Hyori Tattoo, July Month 2020, Holy Roman Empire Time Period, Carryminati Instagram, Cost Of Living In Belarus For International Student, Adidas Marketing Strategy, Scooby-doo Curse Of The Lake Monster Dvd, Navika Kotia Movies, Jack Harlow - Ghost, Shiny Bulbasaur Evolution, Opposite Word Of Justice, Review Revenge Wears Prada, Next Dundee United Manager Odds Mcbookie, Luke Combs - The Dance Lyrics, Ed Westwick Leighton Meester, Red Riding Hood Wolf, Four Christmases 2, Uniqlo Voucher Online, Self-pity Psychology, Water Edge Meaning In Marathi, Aldo Bensadoun Net Worth, Padma Lek, Sharon Needles Birth Chart, The Old Curiosity Shop (1934 Dvd), Shadow And Bone Synopsis, The Lost Prince Film 2020, Thomas Rhett Offer Code, Van Trach Dutch, Braveheart Digimon Lyrics, Piers Linney Net Worth, Yesterday (2019 Songs), Coroner Season 2 Episode 4 Recap, Colorado Springs Fire 2013, Luke Combs 1 Singles, Caleb Carr Books In Order, Sara Ali Khan And Kartik Relationship, Paterson, Nj Zip Code, Philip Maxwell Son Of Robert Maxwell, Coroner Season 2 Episode 4 Recap, Latvia Population, Renegade Fortnite, Dragons' Den Board Game Pitch, Persuasion On Youtube, The Great Invisible Watch Online, Shabd Movie Ending Explained, Adultery In The Bible, When In Rome Saying History, Iu And Sulli, Tic Tac Candy, Remagnetize Fridge Door Seal, Shreya Dhanwanthary Height, Furry Vengeance Box Office, Photo Album Book, What Is 60 Minutes Overtime, Spartan Face Mask, Present Perfect Continuous Tense Exercises, Importance Of Preschool Friendships, Jerusalem The Movie Watch Online, Fletcher Cox 40-yard Dash, She's All That Cast Now, Weather In Delhi Now, Lauren Potter Net Worth, Dez Bryant Comeback, Horse Stats, Vive L'amour Full Movie Online, Unforgotten Synonym, Giyu Tomioka Quotes, Abhor Sentence, I Heart Huckabees Coincidence Quote, Despise Antonym, The Hangover Trilogy Steelbook, Small Island Synonym, Red Velvet Fandom Color Code, How To Pronounce Bordeaux In French, Hecks Avon, Photo Album Storage Furniture, Helen Ozark,