tyler ross caltech
May 2020 Anya Mitskovets has succesfully defended her Ph.D. thesis on 'Using DNA origami to create hybrid … Tyler Ross PhD Student, Caltech. Along with motor proteins that power movement, these incredibly small structures combine to propel the relatively large cell—like ants steering and powering a car. Powered by.
Led by Ross, a team of Caltech researchers explored how to manipulate the component filaments and motor proteins outside of the cell's natural environment. The Demetriades - Tsafka - Kokkalis Prizes were endowed by a generous grant from Sterge Demetriades and his wife Anna Kokkalis Demetriades. Controlling Forces and Organization in Active Matter. And, how can we control these molecules the way a cell does?"
Caltech researchers have devised a way to manipulate cellular skeletons with light when purified in a test tube. Normally, fluids on these small scales are difficult to manipulate and characterize. We could use aster structures in such a way that they could stir and mix solutions at very small length scales.".
We form a DNA nanotechnology supergroup and frequently collaborate with the Winfree and Qian labs. We had feedback from people who work in DNA nanotechnology and people who work in chemical engineering and fluid dynamics.".
says graduate student Tyler Ross, first author on the study. Two asters (white) form and are guided together with beams of light (dark yellow). This video illustrates how the formation of asters (white) can excite very small-scale fluid flows (black). And, how can we control these molecules the way a cell does?" In previous studies, researchers have taken these molecules out of the cell and put them into test tubes, where the tubules and motor proteins spontaneously group together to organize themselves into star-shaped structures called asters.
Controlling Forces and Organization in Active Matter.
Understanding how cells control movement could one day lead to tiny, bioinspired robots for therapeutic applications.
says graduate student Tyler Ross, first author on the study. You know you have a skeleton, but did you know that your cells have skeletons, too? News 29. The technique offers a way to manipulate structures and study fluid dynamics at a miniscule length scale that is usually difficult to work at; fluids exhibit tricky behaviors at such small volumes.
How asters in a test tube are related to a cytoskeleton powering cell movement, however, is still unclear. Bottom left to right: Tyler Ross, Joaquin Garcia Suarez. Learn more about the past winners. The work is described in a paper appearing in the August 8 issue of the journal Nature. Become a member, and contribute with research news and stories. The Demetriades - Tsafka - Kokkalis Prizes This community is not edited and does not necessarily reflect the views of Nature Research. The Demetriades - Tsafka - Kokkalis Prizes. At Caltech, the pair teamed up with Heun Jin Lee, a staff scientist with extensive expertise in optics, to develop a specialized microscope with which they could view aster formation and direct precise patterns of light.
Tyler Ross. Managed by Caltech Library Updates FAQ Terms Report a Problem Contact. A cash prize is awarded at a special dinner to each PhD candidate selected for the best thesis, publication, or discovery in the following fields: Also a prize in Entrepreneurship or Related Fields is awarded to a graduating student for the best business plan, proposal, start-up, or related efforts at Caltech. The research is a collaboration between the laboratories of Matt Thomson, assistant professor of computational biology and Heritage Medical Research Institute Investigator, and Rob Phillips, Fred and Nancy Morris Professor of Biophysics, Biology, and Physics.
Aug 19, 2019.
Ross developed simple procedures of light patterns to place, move, and merge asters of various sizes. Contributor Nature.
Top left to right: Manuel Bedrossian, Vinayak Narasimhan, Adam Neumann, Division of Engineering and Applied Science. The Demetriades - Tsafka - Kokkalis Prizes are announced at Caltech commencement each year.
The building blocks of the cellular cytoskeleton are thin, tube-like filaments called microtubules that can form together into three-dimensional scaffolds. Funding was provided by the National Institutes of Health, the National Science Foundation, the John Templeton Foundation, the Foundational Questions Institute and the Fetzer Franklin Fund, the UCSF Center for Systems and Synthetic Biology, and the Heritage Medical Research Institute. His research is in guiding biomolecular filaments and motors to form structures and flow fields with patterned light. In test tubes, they linked motor proteins to light-activated proteins that are naturally found in plants, so that the tubules would only organize into asters when light was shining on them.
Top left to right: Manuel Bedrossian, Vinayak Narasimhan, Adam Neumann
Controlling the asters not only allowed for the study of their formation but also enabled the team to build things out of the structures. All rights reserved. Nature Research makes no representations, warranties or guarantees, whether express or implied, that the content on this community is accurate, complete or up to date, and to the fullest extent permitted by law all liability is excluded.
But this is the scale that we're most interested in for studying cells and chemistry; all of molecular biology works on this scale," says Ross.
In addition to Ross, Thomson, Phillips, and Lee, other co-authors are postdoctoral scholar Zijie Qu and graduate student Rachel Banks. Bottom left to right: Tyler Ross, Joaquin Garcia Suarez. Learn more about the family.
This collaboration, notes Thomson, enabled pivotal breakthroughs in the project, which Ross had begun in Thomson's laboratory at UC San Francisco (UCSF) before the two came to Caltech in 2017. The Demetriades - Tsafka - Kokkalis Prizes were endowed by a generous grant from Sterge Demetriades and his wife Anna Kokkalis Demetriades.
We use cookies to help improve your experience. The paper is titled, "Controlling Organization and Forces in Active Matter Through Optically-Defined Boundaries."
Our lab is located at Caltech and we are part of the Biology and Biological Engineering, Computing + Mathematical Science and Computation & Neural Systems divisions.
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