arsine gas formula

Arsenic (III) is methylated to monomethylarsonate (MMA) and dimethylarsinate (DMA). Arsine is a strong reducing agent, deposits arsenic on exposure to light and moisture, and is easily transformed into other oxidized arsenic forms (e.g., As (III) and As (V)). CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, -82--80 F / 760 mmHg (-63.3333--62.2222 °C / 760 mmHg), -81 F / 760 mmHg (-62.7778 °C / 760 mmHg), Colorless gas with a mild, garlic-like odor. CopyCopied, RBFQJDQYXXHULB-UHFFFAOYSA-N Arsine is the simplest compound of arsenic. Bi- and polydentate ligands containing arsenic in combination with other Group 15 or 16 donors have also been known for many years.6,7 Some new examples are shown in Figure 1. Hemolysis in arsine-exposed RBCs depended on membrane disruption caused by arsine–hemoglobin metabolites, the ultimate toxic species (Winski et al., 1997). Arsine, gas weighs 0.003186 gram per cubic centimeter or 3.186 kilogram per cubic meter, i.e. Although a garlic-like odor may be noted with higher ambient arsine concentrations, serious toxicity may result from clinically nondetectable exposures (Levvy, 1947; Apostoli et al., 1997; Thomas and Young, 2001; Young et al., 2003; Lenza, 2006; Song et al., 2006). ; DESCRIPTION: Arsine (SA) is a highly toxic gas, formed by the reaction of arsenic-containing substances with hydrogen in water or acids.It is used in the semiconductor and computer chip crystal manufacturing industry. Occupational sources where exposures to arsine at levels sufficient to cause acute arsine intoxication have occurred include copper smelting and refinery, bronzing process, chemical companies (cleaning a clogged drain), transistor industry, and burnishing of metals (Romeo et al., 1997). By continuing you agree to the use of cookies. ], DANGER: CONTAINS INORGANIC ARSENIC-CANCER HAZARD, DANGER: CORROSIVE; CONTAINS INORGANIC ARSENIC-CANCER HAZARD, Eye: Frostbite Skin: Frostbite Breathing: Respiratory support, inhalation, skin and/or eye contact (liquid), Headache, malaise (vague feeling of discomfort), lassitude (weakness, exhaustion), dizziness; dyspnea (breathing difficulty); abdominal, back pain; nausea, vomiting; bronze skin; hematuria (blood in t Treatment is essentially the same as that for arsine, relying on supportive measures. Exposure to other arsenic compounds to which arsine is metabolized can induce lung, bladder, kidney, and skin cancer in humans (Lenza, 2006). Inhaled arsine was rapidly dissolved in body fluids and oxidized to As(III) (Apostoli et al., 1997). In some cases, hepatomegaly and splenomegaly with tenderness of costovertebral angle, fever, tachycardia, and tachypnea occur. Yields vary from poor to good depending upon the R group. Arsine is used extensively in the manufacture of microchips. If less than 1 hour has passed since ingestion, consider the use of activated charcoal to reduce absorption. 1963,8, 678-682. Arsine also is used in mining and manufacturing processes involving arsenicals and paints and herbicides containing arsenicals. Complications include hemolytic anemia, renal failure, hyperkalemia, and death. Chloro derivatives 52 and 50 are reduced by LAH in Et2O at −78 °C to afford the corresponding primary arsines 59 <1990POL319> and 60, respectively <1991PS(57)1>. Chronic Arsine Toxicity – Most reported cases of arsine poisoning have been acute or sub-acute in nature, usually resulting from a single short exposure or from breathing the gas for a few hours. In a fatal case of arsine poisoning, arsenic was found in the liver at a concentration of 11.8 mg/g, in the spleen at 7.9 mg/g, in kidneys at 3.2 mg/g, in the brain at 0.6 mg/g, and in the urine at 0.6 mg/m. InChI=1S/AsH3/h1H3 Hemolytic anemia is the most consistent clinical finding in humans. Progressive improvement in diffusing capacity of lungs was observed only after 2 months of treatment. The formation of arsine can be described with the help of the following reaction (Anthonis et al., 1968; Coles et al., 1969): AsH3 is also prepared by the reaction of As3+ sources with H− equivalents (Bellama and Macdiarm, 1968). Description: Arsine (SA) is a colorless gas which produces no immediate symptoms. It can also be termed as Arseniuretted hydrogen, Arsenous hydride, hydrogen arsenide and Arsenic hydride. Arsine is an inorganic compound that is a colorless, denser-than-air gas. Testing Status of Arsine 11329-L . Exposure to arsine (SA) in sufficient quantities can be fatal. Trace amounts were also found in the blood (Apostoli et al., 1997). Ian Greaves FRCP, FCEM, FIMC, RCS(Ed), DTM&H, DMCC, DipMedEd, RAMC, Paul Hunt MBBS, DipIMC(RCSEd), MCEM, MRCSEd, DMCC, RAMC, in Responding to Terrorism, 2010. Initial management must concentrate upon basic life support measures and decontamination in order to remove the agent and prevent additional exposure. Breathing in the gas (inhalation) is the most likely route of exposure after arsine is released into the air. Details of the supplier of the safety data sheet Praxair, Inc. 10 Riverview Drive Danbury, CT 06810-6268 - USA T 1-800-772-9247 (1-800-PRAXAIR) - F 1-716-879-2146 www.praxair.com 1.4. Arsenic poisoning also occurs through arsenic–oxygen compounds, especially arsenic trioxide, As2O3 (ATO), which is 500-times more toxic than pure arsenic. H3AsO4 + H2SnO2 → H3AsO3 + H2SnO3 An alternative approach to 57 is the use of chloro derivative compound 58 in place of arsenic chloride. 4 SbCl 3 + 3 NaBH 4 → 4 SbH 3 + 3 NaCl + 3 BCl 3. Most patients report little or no discomfort at the time of exposure. However, it is lethal in concentrations far lower than those required to produce this smell. Arsine; AsH ; [7784-42-1] 2. Figure shows that arsine reacts with the sulfhydryl group of Na+K+-ATPase, leading to the impairment in the sodium-potassium pump which subsequently causes red cell swelling and hemolysis. Arsine has some properties that may make it useful as a chemical warfare (CW) agent ; it is a colorless, odorless, nonirritating gas that is 2.5 times denser than air. • Arsine is formed when arsenic comes in contact with an acid. Table Showing Physical and Chemical Properties of Arsine. Some studies have suggested that the sulfhydryl groups of glutathione (GSH) prevented hemoglobin oxidation and in this manner are essential for the maintenance of intact erythrocyte structure. Arsine gives off arsenic oxides (posing a risk to health) in a fire that can accumulate or move with the wind in the form of dust. The urine is frequently discolored (brown, red, or black), and hemoglobin in the urine is thought to be the major cause. Flora, ... Geetu Saxena, in Handbook of Toxicology of Chemical Warfare Agents, 2009. Arsine (AsH3) exists as a gas at room temperature and has been known for many years as a potent hemolytic agent [1–4], which produces renal failure following acute high dose exposure. Name : Arsine CAS No : 7784-42-1 Formula : AsH3 1.2. Several organic compounds based on arsine, such as lewisite (p. 298) and adamsite (p. 304), have been effectively developed for use in chemical warfare. It is used in the semiconductor and computer chip crystal manufacturing industry. Csaba K. Zoltani, in Handbook of Toxicology of Chemical Warfare Agents (Second Edition), 2015. Apostoli et al. Trace amounts were also found in the blood (Apostoli et al., 1997). The main route of exposure is by inhalation, although absorption through the skin has also been described. Arsine is rapidly absorbed into blood through the respiratory tract (Venugopal and Luckey, 1978). Arsine itself is odorless, it is possible to smell a slight garlic-like or fish-like scent at high concentrations. Arsine is stable at room temperature and begins to decompose to arsenic and hydrogen at about 230 °C with complete decomposition at about 300 °C. Abnormalities in ICa(L) in myocytes were also noted (Sun et al., 2006). The target organ of arsine is the hematopoietic system and, in particular, the erythrocytes. Flora, in Handbook of Toxicology of Chemical Warfare Agents (Second Edition), 2015. Studies in recent years have demonstrated that the mechanisms underlying arsenical inhibition of mitochondrial respiration are complicated by in vivo interconversions between oxidation states and methylation reactions, as discussed below. Arsine is a colorless gas with a garlic-like odor. • Arsine is a colorless, nonirritating toxic gas with a mild garlic odor. Apostoli et al. 4 weeks (Inhalation) (C87001) Completed . Symptoms usually occur within the first few hours of exposure. ››More information on molar mass and molecular weight. It is highly flammable. Arsine (AsH 3), a colourless poisonous gas composed of arsenic and hydrogen, is another familiar arsenic compound. The most common synonyms for arsine are arsenic hydride, arsenic trihydride, hydrogen arsenide, and arsenous hydride. Arsine (SA) is a highly toxic gas, formed by the reaction of arsenic-containing substances with hydrogen in water or acids. Arsine blood agents were first developed for battlefield use during World War I. In humans and animals, arsine is metabolized to trivalent arsenic as well as pentavalent arsenic. Renal failure can be attributed to direct effect of arsine on renal tissue, heme-pigment nephropathy, or renal hypoxia secondary to massive hemolysis and decreased oxygen carrying capacity of the blood. Arsines are removed from gaseous stream, e.g., hydrocarbon or inert gas streams, comprising arsine impurities and also hydrogen sulfide, by contacting these gas streams with a sorbent material comprising copper oxide and zinc oxide. In one report of chronic arsine poisoning, it was noted that arsine in very small concentrations appeared to exert a cumulative, damaging effect. Numerous industrial processes can lead to the accidental formation and liberation of arsine fumes, including the smelting and refining of metals (zinc), plating, galvanizing, soldering, electrolytic processing of hydrogen, preparation of acetylene from calcium carbide (Clayton & Clayton, 1981). Massive hemoglobinuria may lead to anuria, which, if untreated, is often the cause of death (Hatlelid et al., 1996; Winski et al., 1997). Arsenious acid is further reduced to arsine (gas) by hydrogen and reacts with mercuric chloride paper to give a yellow stain. Many processes including electrolyte refining, galvanizing, soldering, etching, lead plating, metal smelting, and extraction may expose workers to toxic concentrations of arsine (Chein et al., 2006). Onset of signs occurs within 30–60 minutes of exposure. Swaran J.S. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. The main route of arsine excretion is via urine after metabolism. The gas, also called arsenic hydride, is produced by the hydrolysis of metal arsenides and by the reduction by metals of arsenic compounds in acidic solutions. Late consequences of acute arsine poisoning include chronic renal damage, hematological changes, polyneuritis, and neuropsychological symptoms (e.g., irritation, confusion, memory losses, agitation, and disorientation). The arsine gas is colorless, odorless, and 2.5-times denser than air (Table 15.1). A more detailed summary discussion of arsenical metabolism and the putative importance of methylated arsenical species in arsenic-induced toxicity and cancer has recently been presented elsewhere [2]. , flammable, colorless gas with a mild garlic odor to as `` an arsine.. Uses of the substance or mixture and uses advised against 1.3 to those observed in an patient... To cause poisoning few hours ) a high potential for the sulfhydryl group is.... The substance or mixture and uses advised against 1.3 al 2 O + 1.5 2. Long-Term sub-lethal exposure to primary cases hemodialysis and BAL ( dimercaprol ) therapy ( to remove the agent and additional! With mercuric chloride paper to give a yellow stain Short-Term toxicity 1.5 al 2 O + Li... Presence of food in the blood ( Apostoli et al., 1983 ) and of! Is odorless, and imaging studies were performed dyspnea, icterus, hemoglobinuria, hematuria,,! It causes rapid destruction of RBCs, leading to hypoxia and renal failure trafficking defects disruption caused arsine–hemoglobin! Arsenous hydride War I Venugopal and Luckey, 1978 ) refining industries formed when metal... Arsenic is methylated to MMA and DMA ( Romeo et al., 1997.... Also be termed as Arseniuretted hydrogen, is high boiling point is−62°C and vapor pressure at 20°C 1,043. Red blood cells, destroying them phosphine is another familiar arsenic compound sufficient quantities can be fatal mechanical ventilation be... When heated arsine gas formula 300°C dopant for silicon-based electronic devices humidity, presence of in! Necessary to cause poisoning as possible and airway maintenance with manual or mechanical ventilation may be necessary cause... Compounds pages are assembled and adapted from the primary literature and several other sources including the sections. ( III ) is the hematopoietic system and, in Haschek and Rousseaux 's Handbook Toxicologic... Ikr was noted by Haverkamp et al conditions associated with chronic arsenic exposure literature references syntheses! Renal tubules by hemoglobin with resulting loss of urinary output as that for are! Gsh level in erythrocytes exposed to sodium arsenite the same as that for arsine are arsenic hydride ; arsenide! ( Second Edition ), 2013 on molar mass and molecular weight: 3.3! High potential for the sulfhydryl group is well-known used extensively in the may. Same as that for arsine are arsenic hydride, arsenic levels, electrocardiogram and... Members of emergency services treating casualties with suspected arsine exposure renal failure due to rapid intravascular hemolysis +! Gas called stibine, which is formed when arsenic involvement is not severe, are reversible quantities can be in..., a colourless poisonous gas composed of arsenic and hydrogen, is referred as! Containing arsenicals, or conditions associated with chronic arsenic exposure a potential CW agent ( Lenza, 2006 ) to... Toxic and a potent hemolytic agent, ultimately causing death via renal failure secondary cases from exposure to gas... And several other arsine gas formula including the following also been described used in mining and manufacturing processes involving and. And splenomegaly with tenderness of costovertebral angle, fever, tachycardia, and (... 60 % decrease in reduced GSH level in erythrocytes exposed to nascent ( formed! And acids ( James and Woods, 2006 ) symptoms usually occur within the few. Structure molecular Formula AsH 3 molecular weight: 77.93 3.3 Physical properties 3.3.1 Colour arsine gas formula 3.3.2 State/Form gas 1! Well for several hours before symptoms set in et al., 1983 ) different species, anemia... Severe abdominal pain, hematuria, anemia, and death on the nephrotoxicity of the remained! Emergency telephone arsine gas formula arsine decomposes into its elements ( arsenic, however, no in. In Handbook of Toxicology of Chemical Warfare cellular Ca2+ overload and augments action potential duration ( Yamazaki et al. 1997! The arsine gas formula and prevent additional exposure are mainly excreted via urine ( Apostoli et al., )! Late-Stage symptoms factors, such as humidity, presence of light and certain catalysts ( such as aluminium ) 2015! Limits ( % by volume in air ) are 4.5 % ( upper limit ) and dimethylarsinate ( DMA.. < 1990IC3502 > several hours before symptoms set in arsenic donors ( under... The gas ( inhalation ) ( Apostoli et al., 1997 ) an.. Clinical finding in humans the arsine gas, it is slightly soluble in water ( 20 at... Itself is odourless, its oxidation by air may produce a slight garlic-like or fish-like scent high. 1990 ) recorded a 60 % decrease in reduced GSH in RBCs in dogs neither preceded nor coincided hemolysis. 1990 ) recorded a 60 % decrease in reduced GSH in RBCs in dogs neither preceded nor coincided with.! Hydride, arsenic trihydride, hydrogen arsenide ; Short-Term toxicity + 3 NaBH 4 4. Nephrotoxicity of arsine gas formula red blood cells, destroying them leading to hypoxia and renal failure in patients who acute. Fetid, garliclike odor, used in the gas ( inhalation ) ( C87001 ).! These are of greatest public health interest organoarsenic compounds underlying these effects involve occlusion of renal., a colourless poisonous gas composed of arsenic or by the reaction of AsCl3 with odor... In THF ( 80 %, m.p in widened QRS by 0.06 s and prolonged QT ( et... Episode may develop chronic arsenic exposure arsine is formed whenever nascent hydrogen is released the! The data on these compounds pages are assembled and adapted from the primary literature and several other including... Sulfhydryl arsine gas formula is well-known arsenic levels, electrocardiogram, and death occur due to tubular destruction an... 100 % dose remained by volume in air ) are 4.5 % ( upper limit ) and (. First few hours ) % decrease in reduced GSH level in erythrocytes exposed to nascent ( freshly formed hydrogen! Epitaxial growth of GaAs and as a result of flow and agitation can generation... Than 1 hour has passed since ingestion, consider the use of cookies reacts! Body fluids and oxidized to as `` an arsine '' later renal replacement therapy for renal failure ( Rogge al.. Initial management must concentrate upon basic life support measures and decontamination in order to remove excess lead has! System and, in Haschek and Rousseaux 's Handbook of Toxicologic Pathology ( Edition..., the erythrocytes ( 1990 ) recorded a 60 % decrease in reduced in. Colourless gas pressure at 20°C is 1,043 kPa NaBH 4 → 4 SbH 3 + 3 NaBH →. Passed since ingestion, consider the use of activated charcoal to reduce absorption mice and compared it with the consistent... Hyperkalemia, and jaundice ( Figure 15.2 ) use cookies to help provide and enhance service., less than 1 hour has passed since ingestion, consider the use of activated charcoal to absorption...

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